Tanzawaic Acid Derivatives from the Marine-Derived Penicillium steckii as Inhibitors of RANKL-Induced Osteoclastogenesis.
Yingying SongYanhui TanJianglian SheChunmei ChenJiamin WangYiwei HuXiaoyan PangJun-Feng WangYong-Hong LiuPublished in: Journal of natural products (2023)
Seven new tanzawaic acid derivatives, steckwaic acids E-K ( 1 - 7 ), and one new benzene derivate ( 8 ), together with seven known tanzawaic acid analogues ( 9 - 16 ) were isolated from the marine algicolous fungus Penicillium steckii SCSIO 41040. The structures and absolute configurations of these new compounds ( 1 - 8 ) were determined by spectroscopic analyses, X-ray diffraction, and comparison of ECD spectra to calculations. Compounds 2 , 10 , and 15 inhibited lipopolysaccharide (LPS)-induced nuclear factor kappa-B (NF-κB) with IC 50 values of 10.4, 18.6, and 15.2 μM, respectively. Compound 2 could suppress the receptor activator of NF-κB ligand (RANKL)-induced osteoclast differentiation in bone marrow macrophage cells (BMMCs). To the best of our knowledge, this is the first report of osteoclastogenesis inhibitory activity for tanzawaic acid derivatives.
Keyphrases
- nuclear factor
- lps induced
- toll like receptor
- inflammatory response
- bone marrow
- high glucose
- high resolution
- bone loss
- healthcare
- molecular docking
- structure activity relationship
- induced apoptosis
- density functional theory
- drug induced
- computed tomography
- immune response
- magnetic resonance
- cell cycle arrest
- molecular dynamics
- mass spectrometry
- cell proliferation
- endoplasmic reticulum stress