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Tanzawaic Acid Derivatives from the Marine-Derived Penicillium steckii as Inhibitors of RANKL-Induced Osteoclastogenesis.

Yingying SongYanhui TanJianglian SheChunmei ChenJiamin WangYiwei HuXiaoyan PangJun-Feng WangYong-Hong Liu
Published in: Journal of natural products (2023)
Seven new tanzawaic acid derivatives, steckwaic acids E-K ( 1 - 7 ), and one new benzene derivate ( 8 ), together with seven known tanzawaic acid analogues ( 9 - 16 ) were isolated from the marine algicolous fungus Penicillium steckii SCSIO 41040. The structures and absolute configurations of these new compounds ( 1 - 8 ) were determined by spectroscopic analyses, X-ray diffraction, and comparison of ECD spectra to calculations. Compounds 2 , 10 , and 15 inhibited lipopolysaccharide (LPS)-induced nuclear factor kappa-B (NF-κB) with IC 50 values of 10.4, 18.6, and 15.2 μM, respectively. Compound 2 could suppress the receptor activator of NF-κB ligand (RANKL)-induced osteoclast differentiation in bone marrow macrophage cells (BMMCs). To the best of our knowledge, this is the first report of osteoclastogenesis inhibitory activity for tanzawaic acid derivatives.
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