Association of haemolysis markers, blood viscosity and microcirculation function with organ damage in sickle cell disease in sub-Saharan Africa (the BIOCADRE study).
Brigitte RanqueMor DiawAbdoul Karim DembeleClaudine LapoumeroulieLucile OffredoOumar TessougueSerigne Mourtalla GueyeDapa DialloSaliou DiopYves Colin-AronoviczXavier JouvenOlivier Blanc-BrudePierre-Louis TharauxSylvain Le JeunePhilippe ConnesMarc RomanaCaroline Le Van KimPublished in: British journal of haematology (2023)
Sickle cell anaemia (SCA) is a monogenic disease with a highly variable clinical course. We aimed to investigate associations between microvascular function, haemolysis markers, blood viscosity and various types of SCA-related organ damage in a multicentric sub-Saharan African cohort of patients with SCA. In a cross-sectional study, we selected seven groups of adult patients with SS phenotype in Dakar and Bamako based on the following complications: leg ulcer, priapism, osteonecrosis, retinopathy, high tricuspid regurgitant jet velocity (TRV), macro-albuminuria or none. Clinical assessment, echocardiography, peripheral arterial tonometry, laboratory tests and blood viscosity measurement were performed. We explored statistical associations between the biological parameters and the six studied complications. Among 235 patients, 58 had high TRV, 46 osteonecrosis, 43 priapism, 33 leg ulcers, 31 retinopathy and 22 macroalbuminuria, whereas 36 had none of these complications. Multiple correspondence analysis revealed no cluster of complications. Lactate dehydrogenase levels were associated with high TRV, and blood viscosity was associated with retinopathy and the absence of macroalbuminuria. Despite extensive phenotyping of patients, no specific pattern of SCA-related complications was identified. New biomarkers are needed to predict SCA clinical expression to adapt patient management, especially in Africa, where healthcare resources are scarce.
Keyphrases
- risk factors
- healthcare
- sickle cell disease
- end stage renal disease
- oxidative stress
- computed tomography
- chronic kidney disease
- ejection fraction
- high throughput
- physical activity
- left ventricular
- heart failure
- single cell
- prognostic factors
- patient reported outcomes
- transcatheter aortic valve replacement
- coronary artery disease
- peritoneal dialysis
- atrial fibrillation
- binding protein
- long non coding rna