Genetic meta-analysis of levodopa induced dyskinesia in Parkinson's disease.

Alejandro Martinez Carrasco Raquel Real Michael A Lawton Hirotaka Iwaki Manuela M X Tan Lesley Yue Wu Nigel M Williams Camille B CarrollMichele T M HuDonald G Grosset John A Hardy Mina Ryten Thomas Foltynie Yoav Ben-Shlomo Maryam Shoai Huw R Morris

Published in: medRxiv : the preprint server for health sciences (2023)

In this association study, we have found three novel genetic variants associated with LiD, as well as confirming reports that variability in ANKK1 and BDNF loci were significantly associated with LiD probability. A PRS nominated from our time-to-LiD meta-analysis significantly differentiated between PD-LiD and PD. In addition, we have found female gender, young PD onset and anxiety to be significantly associated with LiD.

Keyphrases

systematic review
meta analyses
genome wide
case control
high glucose
diabetic rats
emergency department
dna methylation
physical activity
depressive symptoms
drug induced
stress induced
middle aged
genome wide association study