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Genetic meta-analysis of levodopa induced dyskinesia in Parkinson's disease.

Alejandro Martinez CarrascoRaquel RealMichael A LawtonHirotaka IwakiManuela M X TanLesley Yue WuNigel M WilliamsCamille B CarrollMichele T M HuDonald G GrossetJohn A HardyMina RytenThomas FoltynieYoav Ben-ShlomoMaryam ShoaiHuw R Morris
Published in: medRxiv : the preprint server for health sciences (2023)
In this association study, we have found three novel genetic variants associated with LiD, as well as confirming reports that variability in ANKK1 and BDNF loci were significantly associated with LiD probability. A PRS nominated from our time-to-LiD meta-analysis significantly differentiated between PD-LiD and PD. In addition, we have found female gender, young PD onset and anxiety to be significantly associated with LiD.
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