Polygenic Interactions With Environmental Exposures in Blood Pressure Regulation: The HUNT Study.
Karsten ØvretveitEmma M L IngeströmMichail SpitierisVinicius TraganteLaurent F ThomasIngelin SteinslandBen Michael BrumptonDaníel F GuðbjartssonHilma HólmKári StefánssonUlrik WisløffKristian HveemPublished in: Journal of the American Heart Association (2024)
Individuals that are genetically susceptible to high BP may be more vulnerable to common acquired risk factors for hypertension, but these effects appear to be modifiable. The gene-dependent influence of several common acquired risk factors indicates the potential of genetic data combined with lifestyle assessments in risk stratification, and gene-environment-informed risk modeling in the prevention and management of hypertension.
Keyphrases
- blood pressure
- genome wide
- copy number
- risk factors
- hypertensive patients
- heart rate
- human health
- genome wide identification
- cardiovascular disease
- physical activity
- metabolic syndrome
- dna methylation
- electronic health record
- weight loss
- big data
- risk assessment
- adipose tissue
- type diabetes
- transcription factor
- climate change
- arterial hypertension
- data analysis
- life cycle