A complex of cadherin 17 with desmocollin 1 and p120-catenin regulates colorectal cancer migration and invasion according to the cell phenotype.

Rubén A BartoloméLaura Pintado-BerninchesÁngela Martín-RegaladoJavier RoblesTania Calvo-LópezMarina Ortega-ZaperoCelia Llorente-SáezIssam BoukichMaría Jesús Fernandez-AceñeroJosé Ignacio Casal

Published in: Journal of experimental & clinical cancer research : CR (2024)

These findings shed light on the multifaceted roles of CDH17, DSC1, and p120-catenin in CRC metastasis, offering insights into potential therapeutic interventions for targeting desmosomal cadherins in poorly-differentiated carcinomas.

Keyphrases

epithelial mesenchymal transition
cell proliferation
single cell
cell therapy
physical activity
high grade
stem cells
signaling pathway
cell migration
cell adhesion