Incidence of thyroid dysfunction following initiation of amiodarone treatment in patients with and without heart failure: a nationwide cohort study.
Sam Aiyad AliMads ErsbøllNaja Emborg VindingJawad Haider ButtRasmus RørthChristian SelmerLucas Malta WestergaardUlrik Madvig MogensenPeter E WeekeChristian JonsFinn GustafssonEmil Loldrup FosboelLars Valeur KøberSøren Lund KristensenPublished in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2023)
Among patients who initiated amiodarone treatment, around 5% had thyroid dysfunction at 1-year follow-up, with a slightly higher incidence in those with HF. A dose-response relationship was observed between the 1-year accumulated amiodarone dose and the subsequent 5-year cumulative incidence of thyroid dysfunction.