Identification of four novel QTL linked to the metabolic syndrome in the Berlin Fat Mouse.

Manuel DelperoDanny ArendsMaximilian SprechertFlorian KrauseOliver KluthAnnette SchürmannGudrun A BrockmannDeike Hesse

Published in: International journal of obesity (2005) (2021)

QTL mapping together with a detailed prioritization approach allowed us to identify candidate genes associated with traits of the metabolic syndrome. In addition, we provided evidence for direct and indirect genetic effects on blood glucose concentration in the insulin-resistant mouse line BFMI861-S1.

Keyphrases

metabolic syndrome
blood glucose
glycemic control
high density
genome wide
insulin resistance
type diabetes
uric acid
adipose tissue
high resolution
blood pressure
dna methylation
gene expression
mass spectrometry
weight loss
genome wide association