Single-cell RNA-seq Revealed that Altered Tumor Infiltrating Lymphocytes in Cirrhotic Liver Indicate Development of Hepatocellular Carcinoma.

Jingxian Duan Peng ZhuYong ZhangTianhao Mu Yingqiang LiRui XiongSu ChenYingmei Li Zhi-Cheng Li Shifu Chen Lei Zhang

Published in: Journal of clinical and translational hepatology (2023)

Decreased naïve T cell infiltration and increased neutrophil infiltration in the liver may indicate the development of HCC in cirrhotic patients. Alterations in blood-resident immune cells may also be a sign of HCC development in cirrhotic patients. The dynamics of the immune cell subsets may serve as novel biomarkers to predict the transition from cirrhosis to HCC.

Keyphrases

single cell
rna seq
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
peripheral blood
patient reported outcomes
patient reported