Curcumin ameliorates peritoneal fibrosis via inhibition of transforming growth factor-activated kinase 1 (TAK1) pathway in a rat model of peritoneal dialysis.

Jun-Li ZhaoTing ZhangXia ShaoJun-Jun ZhuMei-Zi Guo

Published in: BMC complementary and alternative medicine (2019)

Present results demonstrate that curcumin showed a protective effect on PD-related PF and suggest an implication of TAK1, p38 and JNK pathway in mediating the benefical effects of curcumin.

Keyphrases

peritoneal dialysis
transforming growth factor
end stage renal disease
epithelial mesenchymal transition
cell death
protein kinase
drug induced