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First-degree relatives of patients with systemic lupus erythematosus: Autoreactivity but not autoimmunity?

Bogdan PenevGeorgi Hristov VasilevEkaterina Ivanova TodorovaKalina Tumangelova-YuzeirEkaterina Krasimirova KurtevaSimeon Valentinov MonovDobroslav Kyurkchiev
Published in: International journal of rheumatic diseases (2023)
First-degree relatives display unique clinical and immunological profiles, placing them between healthy individuals and SLE patients, with a balance between compensated immune dysregulation and disease-developing potential. A possible association between ANA titer and the number of clinical complaints is observed, which needs to be confirmed in more extensive studies.
Keyphrases
  • systemic lupus erythematosus
  • rheumatoid arthritis
  • disease activity