Impact of sex on antidepressant discontinuation in groups of similar cytochrome P450 phenotypes.
Dylan L KosaskiKristin C ColeJessica A WrightRazan M El MelikSimon KungWayne T NicholsonJonathan G LeungPublished in: The mental health clinician (2023)
We did not detect a significant difference in risk of antidepressant discontinuation rates between males and females even when accounting for cytochrome P450 phenotype. Future studies should account for whether medications that inhibit or induce antidepressant metabolism may be a crucial factor in antidepressant discontinuation.