Association of Cerebrovascular and Alzheimer Disease Biomarkers With Cholinergic White Matter Degeneration in Cognitively Unimpaired Individuals.
Nira CedresDaniel FerreiraMilan NemyAlejandra MachadoJoana B PereiraSara ShamsLars-Olof WahlundAnna ZettergrenOlga StepankovaLenka VyslouzilovaMaria EriksdotterStefan TeipelMichel J GrotheKaj BlennowHenrik ZetterbergMichael SchöllSilke KernIngmar SkoogErik WestmanPublished in: Neurology (2022)
In cognitively unimpaired older individuals, WMLs play a central role in the degeneration of cholinergic pathways. Our findings highlight the importance of WM lesion burden in the elderly population, which should be considered in the development of prevention programs for neurodegeneration and cognitive impairment.