Highly sensitive detection of driver mutations from cytological samples and cfDNA in lung cancer.

Kazutaka FujitaMasayuki NakayamaMasafumi SataYoshiaki NagaiShu HisataNaoko MatoTakuji SuzukiMasashi BandoNobuyuki HizawaKoichi Hagiwara

Published in: Cancer medicine (2021)

Peptide nucleic acid-LNA dual-PCR exhibited an excellent performance, even using cytological samples. PLDP is applicable for the investigation of cfDNA. The combination of bronchoscopy and PLDP is attractive and will expand the utility of bronchoscopy in clinical practice.

Keyphrases

nucleic acid
clinical practice
real time pcr
fine needle aspiration
label free
loop mediated isothermal amplification
fluorescent probe
living cells
solid phase extraction