Lenvatinib inhibits the growth of gastric cancer patient-derived xenografts generated from a heterogeneous population.

John D KaralisLynn Y YoonSuntrea T G HammerChangjin HongMin ZhuIbrahim NassourMichelle R JuShu XiaoEsther C Castro-DubonDeepak AgrawalJorge SuarezScott I ReznikJohn C MansourPatricio M PolancoAdam C YoppHerbert J ZehTae Hyun HwangHao ZhuMatthew R PorembkaSam C Wang

Published in: Journal of translational medicine (2022)

Nude mice are a superior platform than NSG mice for generating PDXs from gastric cancer patients. Lenvatinib showed promising antitumor activity in PDXs established from a diverse Western patient population and warrants further investigation in gastric cancer.

Keyphrases

high fat diet induced
case report
high throughput
south africa
type diabetes
insulin resistance
single cell