Regulation of OATP1B1 Function by Tyrosine Kinase-mediated Phosphorylation.
Elizabeth R HaydenMingqing ChenKyle Z PasquarielloAlice A GibsonJames J PettiShichen ShenJun QuSu Sien OngTaosheng ChenYan JinMuhammad Erfan UddinKevin M HuangAviv PazAlex SparreboomShuiying HuJason A SprowlPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
A novel kinase-dependent posttranslational mechanism of OATP1B1 activation was identified and interference with this process by TKIs can influence the elimination of a broad range of xenobiotic substrates.