Therapeutic potential for insulin on type 1 diabetes-associated periodontitis: Analysis of experimental periodontitis in streptozotocin-induced diabetic rats.

Toru NishikawaYuki SuzukiNoritaka SawadaYasuko KobayashiNobuhisa NakamuraMegumi MiyabeShin-Ichi MiyajimaKei AdachiTomomi MinatoMakoto MizutaniTaku ToriumiNorikazu OhnoTakeshi KikuchiMasaki HondaToshihide NoguchiAkio MitaniTatsuaki MatsubaraKeiko Naruse

Published in: Journal of diabetes investigation (2020)

There were abnormalities of periodontal tissue even without the induction of periodontitis in streptozotocin-induced diabetic rats. Insulin treatment significantly ameliorated periodontitis without local periodontitis treatment in diabetic rats. These data suggest the therapeutic impacts of insulin on periodontitis in type 1 diabetes.

Keyphrases

diabetic rats
type diabetes
oxidative stress
glycemic control
insulin resistance
cardiovascular disease
electronic health record
metabolic syndrome
machine learning
adipose tissue
skeletal muscle
weight loss
high fat diet
artificial intelligence
diabetic nephropathy