Targeted Inhibition of Aggrecanases Prevents Articular Cartilage Degradation and Augments Bone Mass in the STR/Ort Mouse Model of Spontaneous Osteoarthritis.
Ioannis KanakisKe LiuBlandine PouletBehzad JavaheriRobert J van 't HofAndrew A PitsillidesGeorge Bou-GhariosPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2019)
The results provide evidence that [-1A]TIMP-3-mediated inhibition of aggrecanases can protect against cartilage degradation in a naturally occurring mouse model of OA, and they highlight a novel role that aggrecanase inhibition may play in increased bone mass.