Knecorticosanones C-H from the fruits of Knema globularia (Lam.) warb.

Chindawadee ChuenbanAonnicha SombatsriThurdpong SribuhomChanakan PornchooAuemduan Prawan Sarawut Tontapha Vittaya Amornkitbamrung Chavi Yenjai

Published in: RSC advances (2021)

Six undescribed polyketides, 1-6, were discovered from the fruits of Knema globularia (Lam.) warb. Two known polyketides and three known lignans were also isolated. Cytotoxicities against HepG2 and KKU-M156 cells of all polyketides were evaluated. Compound 1 displayed the most cytotoxic activity against HepG2 and KKU-M156 cell lines with IC 50 values of 1.57 ± 0.37 and 1.78 ± 0.14 μg mL -1 , respectively. The structure of all isolates was identified using spectroscopic methods including NMR, IR, MS and ECD.

Keyphrases

induced apoptosis
cell cycle arrest
magnetic resonance
mass spectrometry
molecular docking
multiple sclerosis
high resolution
ms ms
endoplasmic reticulum stress
solid state
molecular dynamics simulations