Genetic polymorphisms associated with pediatric-onset type 2 diabetes: A family-based transmission disequilibrium test and case-control study.

América L Miranda-LoraMario Molina-DíazMiguel CruzRocío Sánchez-UrbinaNancy L Martínez-RodríguezBriceida López-MartínezMiguel Klünder-Klünder

Published in: Pediatric diabetes (2019)

These findings suggest that certain SNPs associated with obesity and other metabolic traits may also be involved in risk of pediatric-onset T2D in Mexican families. We also identified preferential transmission of parental alleles in some variants.

Keyphrases

type diabetes
insulin resistance
genome wide
metabolic syndrome
weight loss
cardiovascular disease
glycemic control
dna methylation
high fat diet induced
adipose tissue
skeletal muscle
physical activity
body mass index
young adults