The Effect of Polymorphisms and Other Biomarkers on Infliximab Exposure in Paediatric Inflammatory Bowel Disease: Development of a Population Pharmacokinetic Model.

Susana Clemente-BautistaIñaki F TrocónizÓscar Segarra-CantónSara Salvador-MarínCarlos J Parramón-TeixidóMarina Álvarez-BeltránLuís A López-FernándezHelena ColomMaria J Cabañas-PoyMaria Q Gorgas-TornerMarta Miarons

Published in: Paediatric drugs (2024)

A popPK model utilising weight, albumin, FC, ESR, and the SNP rs1048610 accurately predicted infliximab trough concentrations in children with IBD.

Keyphrases

ulcerative colitis
young adults
emergency department
body mass index
physical activity
weight loss