Oral Intragastric DMBA Administration Induces Acute Lymphocytic Leukemia and Other Tumors in Male Wistar Rats.

Omar S El-MasryHussain Abdullah AlhawajMuaz O Fagere Amani Y Owaidah Aisha M AlAmriKhaldoon Alsamman

Published in: Journal of experimental pharmacology (2022)

These results suggest the pleiotropic potential of DMBA in the induction of multiple types of malignancies, including leukemia. This could be used as a model to validate therapeutic targets for leukemia and other induced malignancies.

Keyphrases

acute myeloid leukemia
bone marrow
drug induced
liver failure
diabetic rats
respiratory failure
intensive care unit
oxidative stress
human health
extracorporeal membrane oxygenation