Annotation and functional characterization of long noncoding RNAs deregulated in pancreatic adenocarcinoma.

Vinicius Ferreira da PaixãoOmar Julio SosaDiogo Vieira da Silva PellegrinaBianca DazzaniThalita Bueno CorrêaEster Risério BertoldiLuís Bruno da Cruz E Alves-de-MoraesDiogo de Oliveira PessoaVictoria de Paiva OliveiraRicardo Alberto Chiong ZevallosLilian Cristina RussoFabio Luis FortiJoão Eduardo FerreiraHelano Carioca FreitasJosé JukemuraMarcel Cerqueira César MachadoMaria Dirlei BegnamiJoão Carlos SetubalDaniela Sanchez BassèresEduardo Moraes Reis

Published in: Cellular oncology (Dordrecht) (2022)

Our study expands the repertoire of lncRNAs deregulated in PDAC, thereby revealing novel candidate biomarkers for patient risk stratification. It also provides a roadmap for functional assays aimed to characterize novel mechanisms of action of lncRNAs in pancreatic cancer, which could be explored for therapeutic development.

Keyphrases

case report
network analysis
high throughput
rna seq
genome wide identification
single cell