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Multimodal investigation of melanopsin retinal ganglion cells in Alzheimer's disease.

Chiara La MorgiaMicaela MitoloMartina RomagnoliMichelangelo Stanzani MaseratiStefania EvangelistiMaddalena De MatteisSabina CapellariClaudio BianchiniClaudia TestaGilles VandewalleAurelia SantoroMichele CarbonelliPietro D'AgatiMarco FilardiPietro AvanziniPiero BarboniCorrado ZenesiniFlavia BaccariRocco LiguoriCaterina TononRaffaele LodiValerio Carelli
Published in: Annals of clinical and translational neurology (2023)
Overall, the results of this multimodal innovative approach clearly document a dysfunctional mRGC system at early stages of disease as a relevant contributing factor for circadian impairment in AD providing also support to the use of light therapy in AD.
Keyphrases
  • induced apoptosis
  • pain management
  • cell cycle arrest
  • cognitive decline
  • oxidative stress
  • chronic pain