Multimodal investigation of melanopsin retinal ganglion cells in Alzheimer's disease.

Chiara La MorgiaMicaela MitoloMartina RomagnoliMichelangelo Stanzani MaseratiStefania EvangelistiMaddalena De MatteisSabina CapellariClaudio BianchiniClaudia TestaGilles VandewalleAurelia SantoroMichele CarbonelliPietro D'AgatiMarco FilardiPietro AvanziniPiero BarboniCorrado ZenesiniFlavia BaccariRocco LiguoriCaterina TononRaffaele LodiValerio Carelli

Published in: Annals of clinical and translational neurology (2023)

Overall, the results of this multimodal innovative approach clearly document a dysfunctional mRGC system at early stages of disease as a relevant contributing factor for circadian impairment in AD providing also support to the use of light therapy in AD.

Keyphrases

induced apoptosis
pain management
cell cycle arrest
cognitive decline
oxidative stress
chronic pain