IgM monoclonal gammopathy with heavy-and-light-chain amyloidosis resembling fibrillary glomerulonephritis determined by tandem mass spectrometry: a case report.
Misa AdachiMineaki KitamuraKumiko MutaAkihiro MaekawaTadashi UramatsuMasato TadokoroSatoshi FunakoshiSatoshi HisanoNaomi KuwaharaAkira ShimizuHiroshi MukaeTomoya NishinoPublished in: BMC nephrology (2020)
We reported a case of μ and κ chain AHL resembling FGN requiring LMD/MS for definitive diagnosis. Since FGN and amyloidosis exhibit pathological findings, even if Congo red staining is positive, LMD/MS needs to be considered in cases atypical pathological findings, such as silver stain positivity or thicker fibrils.
Keyphrases
- tandem mass spectrometry
- mass spectrometry
- liquid chromatography
- ultra high performance liquid chromatography
- high performance liquid chromatography
- gas chromatography
- multiple myeloma
- ms ms
- multiple sclerosis
- simultaneous determination
- high resolution mass spectrometry
- high resolution
- gold nanoparticles
- locally advanced
- radiation therapy