An immunologically relevant rodent model demonstrates safety of therapy using a tumour-specific IgE.
D H JosephsM NakamuraH J BaxT S DodevG MuirheadL SaulP KaragiannisK M IlievaS CrescioliP GazinskaN WoodmanC LombardelliS KareemaghayC SelkirkH LentferC BartonS CanevariM FiginiN DownesD DombrowiczC J CorriganF O NestleP S JonesH J GouldP J BlowerS TsokaJ F SpicerSophia N KaragiannisPublished in: Allergy (2018)
Our findings indicate safety of MOv18 IgE, in conjunction with efficacy and immune activation, supporting the translation of this therapeutic approach to the clinical arena.
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