Methionine deficiency facilitates antitumour immunity by altering m 6 A methylation of immune checkpoint transcripts.
Ting LiYue-Tao TanYan-Xing ChenXiao-Jun ZhengWen WangKun LiaoHai-Yu MoJunzhong LinWei YangHai-Long PiaoDe-Sheng WangHuai-Qiang JuPublished in: Gut (2022)
Methionine and YTHDF1 play a critical role in anticancer immunity through regulating the functions of T cells. Targeting methionine metabolism or YTHDF1 could be a potential new strategy for cancer immunotherapy.