Age at antiretroviral therapy initiation and cell-associated HIV-1 DNA levels in HIV-1-infected children.
Louise KuhnMaria PaximadisBianca Da Costa DiasShayne LoubserRenate StrehlauFaeezah PatelStephanie ShiauAshraf CoovadiaElaine J AbramsCaroline T TiemessenPublished in: PloS one (2018)
Cell-associated HIV-1 DNA levels measured after more than 4 years on ART were lower the younger the age of the child when ART was initiated. This marker of the size of the viral reservoir also predicted subsequent viral rebound/treatment failure while ART was sustained. The results provide additional evidence of the benefits of prompt diagnosis and early ART initiation in newborns and infants.
Keyphrases
- antiretroviral therapy
- hiv infected
- human immunodeficiency virus
- hiv positive
- hiv infected patients
- hiv aids
- single cell
- sars cov
- cell therapy
- circulating tumor
- cell free
- single molecule
- pregnant women
- young adults
- mental health
- preterm infants
- low birth weight
- hepatitis c virus
- stem cells
- bone marrow
- gestational age
- smoking cessation