Genetically Determined Levels of mTOR-Dependent Circulating Proteins and Risk of Multiple Sclerosis.

Yao-Chen ZhangKe-Yi FanQi WangJing-Xi HuQian WangHe-Yi ZhangShan SongRong ZhaoJun QiaoSheng-Xiao Zhang

Published in: Neurology and therapy (2023)

Molecules in the mTOR signaling pathway may bidirectionally regulate the occurrence and development of MS. PKC-α is a protective factor, while RP-S6K is a risk factor. Further explorations of pathways underlying the association between mTOR-dependent proteins and MS are required. PKC-α and RP-S6K might be used as future therapeutic targets for screening high-risk individuals and potentially improving opportunities for targeted prevention strategies.

Keyphrases

multiple sclerosis
cell proliferation
signaling pathway
mass spectrometry
ms ms
risk factors
white matter
risk assessment
pi k akt
cancer therapy
protein kinase
drug delivery
induced apoptosis