Insulin Resistance in Women Correlates with Chromatin Histone Lysine Acetylation, Inflammatory Signaling, and Accelerated Aging.
Christina M VidalJackelyn A Alva-OrnelasNancy Zhuo ChenParijat SenapatiJerneja TomsicVanessa Myriam RoblesCristal RestoNancy SanchezAngelica SanchezTerry HyslopNour EmwasDana AljaberNick BachelderErnest MartinezDavid AnnVeronica JonesRobert A WinnLucio MieleAugusto C OchoaEric C DietzeRama NatarajanDustin SchonesVictoria E SeewaldtPublished in: Cancers (2024)
This study shows that insulin-resistant women have increased chromatin acetylation/opening, inflammation, and, perhaps, accelerated aging. Given the role that inflammation plays in cancer initiation and progression, these studies provide a potential mechanistic link between insulin resistance and cancer.
Keyphrases
- polycystic ovary syndrome
- oxidative stress
- papillary thyroid
- insulin resistance
- type diabetes
- dna damage
- gene expression
- squamous cell
- transcription factor
- genome wide
- pregnancy outcomes
- metabolic syndrome
- squamous cell carcinoma
- lymph node metastasis
- skeletal muscle
- breast cancer risk
- high fat diet
- pregnant women
- young adults
- weight loss