Genome-Wide Interaction Analysis of Genetic Variants With Menopausal Hormone Therapy for Colorectal Cancer Risk.
Yu TianAndre E KimStephanie A BienYi LinConghui QuTabitha A HarrisonRobert Carreras-TorresVirginia Díez-ObreroNiki DimouDavid A DrewAkihisa HidakaJeroen R HuygheKristina M JordahlJohn MorrisonNeil MurphyMireia Obón-SantacanaCornelia M UlrichJennifer OseAnita R PeoplesEdward A Ruiz-NarvaezAnna ShcherbinaMariana C SternYu-Ru SuFranzel J B van DuijnhovenVolker ArndtJames W BaurleySonja I BerndtD Timothy BishopHermann BrennerDaniel D BuchananAndrew T ChanJane C FigueiredoSteven GallingerStephen B GruberSophia HarlidMichael HoffmeisterMark E JenkinsAmit D JoshiTemitope O KekuSusanna C LarssonLoic Le MarchandLi LiGraham G GilesJonathan BeesleyHongmei NanRami NassirShuji OginoArif BudiartoElizabeth A PlatzJohn D PotterRoss L PrenticeGad RennertLori C SakodaRobert E SchoenMartha L SlatteryStephen N ThibodeauBethany Van GuelpenKala VisvanathanEmily WhiteAlicja WolkMichael O WoodsAnna H WuPeter T CampbellGraham CaseyDavid V ContiMarc J GunterAnshul KundajeJuan Pablo LewingerVictor MorenoPolly A NewcombBens PardameanDuncan C ThomasKonstantinos K TsilidisUlrike PetersW James GaudermanLi HsuJenny Chang-ClaudePublished in: Journal of the National Cancer Institute (2022)
Genetic variants that modify the association between MHT and CRC risk were identified, offering new insights into pathways of CRC carcinogenesis and potential mechanisms involved.