The spatial extent of tauopathy on [ 18 F]MK-6240 tau PET shows stronger association with cognitive performances than the standard uptake value ratio in Alzheimer's disease.
Thomas GérardLise ColmantVincent MalotauxYasmine SalmanLara HuygheLisa QuenonLaurence DricotAdrian IvanoiuRenaud LhommelBernard J HanseeuwPublished in: European journal of nuclear medicine and molecular imaging (2024)
F]MK-6240 tau PET in terms of EOT rather than SUVr significantly increases the correlation with cognitive performances. Quantification in the mesiotemporal lobe is the most useful to diagnose preclinical AD or prodromal AD.