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Efflux systems as a target for anti-biofilm nanoparticles: perspectives on emerging applications.

Robert Musiol
Published in: Expert opinion on therapeutic targets (2023)
The potential of nanoparticles to act as potent antibacterial agents through efflux pump inhibition remains tantalizing, although hindered by limited mechanistic understanding. From the burgeoning research landscape nanoparticles emerge as a novel direction for shaping antimicrobial drug design. Notably, beyond their contribution to drug resistance, efflux pumps play a pivotal role in biofilm development. The deliberate disruption of these pumps can effectively reduce biofilm adhesion and maturation. More details however are needed to exploit this potential.
Keyphrases
  • staphylococcus aureus
  • pseudomonas aeruginosa
  • biofilm formation
  • candida albicans
  • cystic fibrosis
  • human health
  • walled carbon nanotubes
  • emergency department
  • single cell
  • escherichia coli
  • climate change
  • drug induced