Tristaenone A : A New Anti-Inflammatory Compound Isolated from the Australian Indigenous Plant Tristaniopsis laurina .
Shintu MathewXian ZhouGerald MünchFrancis BodkinMatthew WallisFeng LiRitesh RajuPublished in: Molecules (Basel, Switzerland) (2022)
Inspired by ethnopharmacological knowledge, we conducted a bioassay-guided fractionation of the leaves of Tristaniopsis laurina which led to the discovery of a new anti-inflammatory compound, tristaenone A ( 1 ). The structure was elucidated by detailed spectroscopic data analysis, and the absolute configuration was established using X-ray crystallography analysis. Tristaenone A ( 1 ) suppressed LPS and IFN-γ-induced NO, TNF-α and IL-6 production in RAW 264.7 cells with IC 50 values of 37.58 ± 2.45 μM, 80.6 ± 5.82 μM and 125.65 ± 0.34 μM, respectively. It also inhibited NF-κB nuclear translocation by 52.93 ± 14.14% at a concentration of 31.85 μM.
Keyphrases
- anti inflammatory
- data analysis
- induced apoptosis
- signaling pathway
- cell cycle arrest
- rheumatoid arthritis
- healthcare
- small molecule
- high resolution
- oxidative stress
- high glucose
- diabetic rats
- molecular docking
- lps induced
- pi k akt
- dendritic cells
- high throughput
- inflammatory response
- cell death
- mass spectrometry
- essential oil