Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140.

Mohammed GhiboubJan KosterPeter D CraggsAndrew Y F Li YimAnthony ShillingsSue HutchinsonRyan P BinghamKelly GatfieldIshtu L HagemanGang YaoHeather P O'KeefeAaron CoffinAmish PatelLisa A SloanDarren J MitchellThomas G HayhowLaurent LunvenRobert J WatsonChristopher E BluntLee A HarrisonGordon BrutonUmesh KumarNatalie HamerJohn R SpaullDanny A ZwijnenburgOlaf WeltingTheodorus B M HakvoortAnje A Te VeldeJohan van LimbergenPeter HennemanRab K PrinjhaMenno P J de WintherNicola R HarkerDavid F ToughWouter J de Jonge

Published in: BMC biology (2022)

This study identifies SP140 as a druggable epigenetic therapeutic target for CD.

Keyphrases

dna methylation
gene expression
genome wide
oxidative stress
protein protein
small molecule
amino acid