Overview of the Biological Activity of Anthraquinons and Flavanoids of the Plant Rumex Species.
Dmitriy A BerilloMarzhan KozhahmetovaLina LebedevaPublished in: Molecules (Basel, Switzerland) (2022)
Rumex confertus belongs to the genus Rumex and is classified as an invasive parasitic plant in agriculture. Despite other Rumex species being widely used in herbal medicine due to their antimicrobial, antioxidant, antitumor, and anti-inflammatory effects, there are almost no information about the potential of Rumex confertus for the treatment of various diseases. In this review we analyzed scientific articles revealing properties of Rumex plant's substances against cancer, diabetes, pathogenic bacterial invasions, viruses, inflammation, and oxidative stress for the past 20 years. Compounds dominating in each composition of solvents for extraction were discussed, and common thin layer chromatography(TLC) and high performance liquid chromatography(HPLC) methods for efficient separation of the plant's extract are included. Physico-chemical properties such as solubility, hydrophobicity (Log P), pKa of flavonoids, anthraquinones, and other derivatives are very important for modeling of pharmacokinetic and pharmacodynamics. An overview of clinical studies for abounded selected substances of Rumex species is presented.
Keyphrases
- high performance liquid chromatography
- oxidative stress
- tandem mass spectrometry
- mass spectrometry
- simultaneous determination
- liquid chromatography
- solid phase extraction
- ms ms
- type diabetes
- cardiovascular disease
- drinking water
- dna damage
- squamous cell carcinoma
- papillary thyroid
- anti inflammatory
- skeletal muscle
- genetic diversity
- high speed
- squamous cell
- high resolution
- adipose tissue
- heat stress
- heat shock
- smoking cessation
- young adults
- replacement therapy
- combination therapy
- heat shock protein
- plant growth
- human health