Extracellular Vesicles Maintain Blood-Brain Barrier Integrity by the Suppression of Caveolin-1/CD147/VEGFR2/MMP Pathway After Ischemic Stroke.

Yiyang LiJiali ChenXingping QuanYing ChenYan HanJinfen ChenLi YangYouhua XuXu ShenRuibing WangYong-Hua Zhao

Published in: International journal of nanomedicine (2024)

Our study firstly demonstrates that BEC and BMSC-EVs administrations maintain BBB integrity via the suppression of Caveolin-1/CD147/VEGFR2/MMP pathway after IS, and the efficacy of BMSC-EVs is superior to that of BEC-EVs.

Keyphrases

blood brain barrier
cerebral ischemia
vascular endothelial growth factor
cell migration
nk cells
atrial fibrillation
brain injury