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Multiplex malaria antigen detection by bead-based assay and molecular confirmation by PCR shows no evidence of Pfhrp2 and Pfhrp3 deletion in Haiti.

Camelia HermanCurtis S HuberSophie JonesLaura SteinhardtMateusz M PlucinskiJean F LemoineMichelle ChangJohn W BarnwellVenkatachalam UdhayakumarEric Rogier
Published in: Malaria journal (2019)
Malaria positive samples in multiple Haitian sites were found to contain the HRP2/3 antigens, and no evidence was found of Pfhrp2/3 deletions. Malaria RDTs based on the detection of the HRP2/3 antigens remain a reliable P. falciparum diagnostic tool as Haiti works towards malaria elimination.
Keyphrases
  • plasmodium falciparum
  • real time pcr
  • dendritic cells
  • loop mediated isothermal amplification
  • label free
  • immune response
  • quantum dots