Population Pharmacokinetic Model for Tramadol and O-desmethyltramadol in Older Patients.

Aymen Ali Al-QurainRichard N UptonRami TadrosMichael S RobertsMichael D Wiese

Published in: European journal of drug metabolism and pharmacokinetics (2022)

Exposure to tramadol increased with increased frailty and reduced CrCL. Prescribers should consider patients frailty status and CrCL to minimise the risk of tramadol toxicity in such cohort of patients.

Keyphrases

end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
prognostic factors
patient reported outcomes
patient reported