Assessment of Bioenergetic Deficits in Patients With Parkinson Disease and Progressive Supranuclear Palsy Using 31P-MRSI.
Jannik PrasuhnMartin GöttlichBritt EbelingSofia KourouFriederike GerkanChristina BodemannSinja S GroßerKatharina ReutherHenrike HanssenNorbert BrüggemannPublished in: Neurology (2022)
Our study shows that mitochondrial dysfunction and bioenergetic depletion contribute to idiopathic Parkinson's disease pathophysiology but not to progressive supranuclear palsy. Combined morphometric and metabolic imaging could serve as an accompanying diagnostic biomarker in the neuroimaging-guided differential diagnosis of these parkinsonian disorders.