Immunomodulatory effects of colchicine on peripheral blood mononuclear cell subpopulations in human obesity: Data from a randomized controlled trial.
Tushar P PatelJordan A LevineDiana M ElizondoBrooke E ArnerArad JainAnkit SaxenaMaria Lopez-OcasioPradeep K DagurOlufisola FamuyiwaSuryaa GuptaZahra Sarrafan-ChaharsoughiAngelique BiancottoJ Philip McCoyAndrew Paul DemidowichJack A YanovskiPublished in: Obesity (Silver Spring, Md.) (2023)
In adults with obesity, colchicine significantly affects circulating leukocyte populations involved in both innate and adaptive immune systems along with the associated inflammatory secretome.
Keyphrases
- peripheral blood
- insulin resistance
- metabolic syndrome
- weight loss
- high fat diet induced
- type diabetes
- weight gain
- immune response
- endothelial cells
- single cell
- electronic health record
- induced pluripotent stem cells
- cell therapy
- oxidative stress
- adipose tissue
- skeletal muscle
- stem cells
- big data
- physical activity
- genetic diversity
- artificial intelligence
- deep learning