Elevated serum complement levels and higher gene copy number of complement C4B are associated with hypertension and effective response to statin therapy in childhood-onset systemic lupus erythematosus (SLE).
Evan MulvihillStacy ArdoinSusan D ThompsonBi ZhouGakit Richard YuEmily KingNora SingerD M LevyHermine I BrunnerYee Ling WuHaikady N NagarajaLaura Eve SchanbergChack-Yung YuPublished in: Lupus science & medicine (2019)
cSLE with hypertension had elevated serum levels of C4 and C3 and higher GCN of C4B; cSLE with ≥2 C4B genes would benefit from statins therapy to prevent atherosclerosis.