PINK1-mediated mitophagy maintains pluripotency through optineurin.

Chaoqun WangKun LiuJiani CaoLiang WangQian ZhaoZheng LiHonghai ZhangQuan ChenTong-Biao Zhao

Published in: Cell proliferation (2021)

The mitophagy receptor OPTN guards ESC mitochondrial homeostasis and pluripotency by scavenging damaged mitochondria through TBK1-activated OPTN binding of PINK1-phosphorylated Ubiquitin.

Keyphrases

embryonic stem cells
nlrp inflammasome
cell fate
oxidative stress
binding protein
cell death
small molecule
endoplasmic reticulum
dna binding
transcription factor