Temporal Ordering of Biomarkers in Dutch-Type Hereditary Cerebral Amyloid Angiopathy.
Emma A KoemansIngeborg RasingSabine VoigtThijs W van HartenReinier G J van der ZwetKanishk KaushikManon R SchipperNelleke van der WeerdErik W van ZwetEllis S Van EttenMatthias J P van OschHinke B KuiperijMarcel M VerbeekGisela M TerwindtSteven M GreenbergMarianne A A van WalderveenMarieke J H WermerPublished in: Stroke (2024)
Our results suggest that amyloid biomarkers in cerebrospinal fluid are the first to become abnormal in CAA, followed by MRI biomarkers for cerebrovascular reactivity and nonhemorrhagic injury and lastly hemorrhagic injury. This temporal ordering probably reflects the pathological stages of CAA and should be taken into account when future therapeutic trials targeting specific stages are designed.