The field of clinical surgery frequently encounters challenges related to atypical wound tissue healing, resulting in the development of persistent chronic wounds or aesthetically displeasing scar tissue. The use of wound dressings crafted from mussel adhesive proteins and hyaluronic acid has demonstrated the potential in mitigating these undesirable outcomes. However, the synergistic effects of these two biomaterials remain underexplored. In this study, we have engineered a versatile, degradable, and biocompatible dressing that comprises recombinant 3,4-dihydroxyphenylalanine (DOPA)-modified mussel adhesive proteins and maleimide-functionalized hyaluronic acid. We have successfully fabricated this biocompatible dressing and conducted comprehensive experimental assessments to confirm its hemostatic, antibacterial, and biocompatible characteristics. Importantly, this dressing exclusively incorporates biologically derived materials characterized by low toxicity and minimal immunogenicity, thus holding immense promise for clinical applications in the field of wound healing.
Keyphrases
- wound healing
- hyaluronic acid
- drug release
- ionic liquid
- minimally invasive
- drug delivery
- surgical site infection
- coronary artery bypass
- oxidative stress
- type diabetes
- quantum dots
- machine learning
- metabolic syndrome
- cancer therapy
- human health
- climate change
- bone regeneration
- artificial intelligence
- percutaneous coronary intervention
- glycemic control
- anti inflammatory
- tandem mass spectrometry