Chloroquine Sensitizes GNAQ/11-mutated Melanoma to MEK1/2 Inhibition.

Amanda TruongJae Hyuk YooMichael T ScherzerJohn Michael S SanchezKali J DaleConan G KinseyJackson R RichardsDonghan ShinPhaedra C Ghazi Michael D OnkenKendall J BlumerShannon J Odelberg Martin McMahon

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

These results suggest that YAP, MEK1/2, and lysosome function are necessary and critical targets for the therapy of GNAQ/11-driven melanoma, and identify trametinib plus hydroxychloroquine as a potential treatment strategy for metastatic uveal melanoma.

Keyphrases

skin cancer
squamous cell carcinoma
small cell lung cancer
pi k akt
basal cell carcinoma
oxidative stress
living cells
mesenchymal stem cells
cell proliferation
replacement therapy
smoking cessation