Sustained Responses of Neutralizing Antibodies Against Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Recovered Patients and Their Therapeutic Applicability.
Yeon-Sook KimAbdimadiyeva AigerimUni ParkYuri KimHyoree ParkJi-Young RheeJae-Phil ChoiWan Beom ParkSang Won ParkYeonjae KimDong-Gyun LimJi-Yeob ChoiYoon Kyung JeonJeong-Sun YangJoo-Yeon LeeHyoung-Shik ShinNam-Hyuk ChoPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)
High titers of neutralizing activity are required for suppressive effect on the viral replication but may not be sufficient to reduce inflammatory lesions upon fatal infection. Therefore, immune sera with high neutralizing activity must be carefully selected for plasma therapy of zoonotic coronavirus infection.