Immune-mediated hemolytic anemia and pure red cell aplasia in a Jack Russell Terrier during treatment for hypoadrenocorticism.
Shunya YokotaMasashi YukiPublished in: Veterinary clinical pathology (2024)
An 11-year-old neutered male Jack Russell Terrier was presented to Yuki Animal Hospital for regenerative anemia during the treatment of hypoadrenocorticism. A blood smear examination showed spherocytes, polychromatic erythrocytes, and erythrocyte ghosts. The direct agglutination test was positive at 37°C. The dog was then diagnosed with immune-mediated hemolytic anemia (IMHA). Although prednisolone and mycophenolate mofetil were administered, the hematocrit and reticulocyte count decreased, and nonregenerative anemia developed. A bone marrow examination was performed to diagnose the cause of the nonregenerative anemia. Histologic and cytologic bone marrow examination revealed a normocellular to hypercellular medulla with severe erythroid hypoplasia. No proliferation of lymphocytes or lymphoblast-appearing cells was observed. This dog was diagnosed with pure red cell aplasia (PRCA). Despite treatment with immunosuppressive agents, the patient died of thrombosis. Although these associations were unclear, this is the first report of PRCA diagnosis following IMHA and while treating hypoadrenocorticism.
Keyphrases
- iron deficiency
- bone marrow
- chronic kidney disease
- mesenchymal stem cells
- single cell
- cell therapy
- stem cells
- induced apoptosis
- healthcare
- peripheral blood
- cell proliferation
- replacement therapy
- cell cycle arrest
- early onset
- pulmonary tuberculosis
- mycobacterium tuberculosis
- smoking cessation
- ultrasound guided
- pi k akt