M1 macrophages induce PD-L1 hi cell-led collective invasion in HPV-positive head and neck squamous cell carcinoma via TNF-α/CDK4/UPS14.

Jiashun WuXin PangXiao YangMei ZhangBingjun ChenHuayang FanHaofan WangXianghua YuYaling TangXin-Hua Liang

Published in: Journal for immunotherapy of cancer (2023)

leader cells and collective tumor invasion, and highlighted the potential of the combination therapy of anti-PD-L1 and CDK4 inhibitor for HPV-positive HNSCC.

Keyphrases

combination therapy
cell migration
cell cycle
high grade
induced apoptosis
cell cycle arrest
single cell
rheumatoid arthritis
cell therapy
cervical cancer screening
oxidative stress
cell death
endoplasmic reticulum stress
risk assessment