A J-shaped relationship between ketones and the risk of diabetic kidney disease in patients with type 2 diabetes: New insights from a cross-sectional study.
Ying LiuJingyu WangFang XuShuang ZhangShanshan CuiYongmei LiXiaoyu WangHui ZhengJunfeng LiYan KongJuhong YangXia JiangBao Cheng ChangPublished in: Diabetes, obesity & metabolism (2023)
A J-shaped relationship between circulating ketone level and DKD risk in patients with T2D was determined. Circulating βOHB in the range of 0.12-0.30 mM was associated with a lower risk of DKD. Further studies are warranted to verify the causality and to elucidate the underlying mechanisms.