Essential role of p21 Waf1/Cip1 in the modulation of post-traumatic hippocampal Neural Stem Cells response.

Francesco ChianiValentina MastrorilliNicole MarchettiAndrea MacioceChiara NappiGeorgios StrimpakosMiriam PasquiniAlessia GambadoroJonathan Isacco BattistiniDebora CutuliLaura PetrosiniSara MarinelliRaffaella ScardigliStefano Farioli Vecchioli

Published in: Stem cell research & therapy (2024)

These data demonstrate for the first time a fundamental role of p21 in modulating the post-traumatic hippocampal neurogenic response, by the regulation of the proliferative and differentiative steps of aNSCs/progenitor populations after brain damage.

Keyphrases

neural stem cells
cerebral ischemia
spinal cord injury
oxidative stress
white matter
big data
brain injury
temporal lobe epilepsy
deep learning
cell fate